Tuesday, December 27, 2011

Congenital Rubella Syndrome

here is the link:  http://pediatrics.about.com/b/2011/12/23/congenital-rubella-syndrome-in-sweden.htm

Sweden is reporting their first case of congenital rubella syndrome in 30 years. The baby, born premature, has a variety of birth defects, as is typical for for a baby born with congenital rubella syndrome.
According to the World Health Organization, the rubella virus "can often lead to serious and sometimes fatal complications in the fetus when an unprotected woman acquires the infection early in pregnancy (congenital rubella infection) or to congenital rubella syndrome in newborns." Birth defects can include deafness, cataracts, cardiac problems, and neurologic abnormalities, including microcephaly and mental retardation.
In one of the last rubella epidemics in the United States, in 1964, there were 12.5 million cases of rubella and 20,000 cases of congenital rubella syndrome, including 11,600 babies who were born deaf, 3,580 blind, and 1,800 mentally retarded. There were also 2,100 neonatal deaths.

Further link on Wikipedia give info regarding Maternal infection, EVEN BEFORE CONCEPTION. http://en.wikipedia.org/wiki/Congenital_rubella_syndrome

Congenital rubella syndrome (CRS) can occur in a developing fetus of a pregnant woman who has contracted rubella during her first trimester. If infection occurs 0–28 days before conception, there is a 43% chance the infant will be affected. If the infection occurs 0–12 weeks after conception, there is a 51% chance the infant will be affected. If the infection occurs 13–26 weeks after conception there is a 23% chance the infant will be affected by the disease. Infants are not generally affected if rubella is contracted during the third trimester, or 26–40 weeks after conception. Problems rarely occur when rubella is contracted by the mother after 20 weeks of gestation and continues to disseminate the virus after birth.

What is it within science that is not looking for a similar infection as the present day cause of autism?


In this PubMed publication, we are made aware that maternal infection with German Measles increased the incidence of Autism >200 fold in affected mothers/fetusesActivation of the Maternal Immune System Alters Cerebellar Development in the Offspring This is NOT the heritibility we have been led to believe the cause, that arrived coincidentally (or NOT) at the same time scientists were looking to fund the Genome Project.

I propose we already have a good idea what causes autism.  There are just too many livelihoods and egos involved.  Too many research facilities needing funding. And it has nothing to do with psychiatry or mothers,although autism and schizophrenia are the bread and butter of that crowd. (Does my cynicism show?)

The answer is simple, and it was right under our noses in 1977.  How much longer will we continue to ignore it? Rubella is not the only viral possibility.  There are thousands of different viruses, I'm sure.  Sexually transmitted virus's could survive undetected in the mother's blood for years. The PubMed Central search for "maternal viral infections autism" returns only 96 hits.

You may or may not be aware of CMV, or  Cytomegalovirus.

The Impact of CMV Infection

Chart: U.S. Children Born with or Developing Long-Term Medical Conditions Each Year. Annual number of children affected. Cytomegalovirus (CMV): 5,500; Fetal Alcohol Syndrome (FAS): 5,000; Down Syndrome: 4,000; Spina Bifida/Anencephaly: 3,000; Pediatric HIV/AIDS: 200; Invasive Haemophilus Influenzae Type B: 60; Congenital Rubella Syndrome (CRS): 10. CMV is the most common congenital (present at birth) viral infection in the U.S. Each year, about 5,500 (1 in 750) children in this country are born with or develop disabilities that result from congenital CMV infection. More children have disabilities due to this disease than other well-known congenital infections and syndromes, including Down syndrome, fetal alcohol syndrome, spina bifida, and pediatric HIV/AIDS.

See how easily this can happen? It is the most common cause of congenital birth defects, and only 1 in 5 pregnant women have heard of it.

I bet David Kirby fans would love me.

http://www.ctl1.com/publicaccess/humanecology/hdru-20091022-eng-ap/#  early manifestation...from 2 to 4 months post implantation. Immune activation trigger ...

http://sfari.org/funding/grants/abstracts/effect-of-abnormal-calcium-influx-on-social-behavior-in-autism excessive calcium

Iodine deficiency - Combined maternal and fetal hypothyroidism:Iodine deficiency is, by a large margin, the most common preventable cause of mental retardation in the world. Without adequate maternal iodine intake, both the fetus and mother are hypothyroid, and if supplemental iodine is not provided, the child may well develop cretinism, with mental retardation, deaf-mutism and spasticity. http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/thyroid_preg.html

http://sfari.org/news-and-opinion/autism-in-the-arts/2011/book-review-autisms-twisted-immune-links-untangled 


pregnancy loss and thyroid treatment  http://www.bmj.com/content/356/bmj.i6865

15 comments:

usethebrainsgodgiveyou said...

http://blog.autismspeaks.org/2012/01/03/commentary-on-the-la-times-series-on-autism/

usethebrainsgodgiveyou said...

http://www.bioscience.org/atlases/fert/htm/develhum/ovul.htm

fetal development pictured day by day. Amazing. Up to day 22 so far.

usethebrainsgodgiveyou said...

http://today.caltech.edu/theater/item?story_id=14483 Infectious Behavior is a kindle download for about $15. This link was on the amazon page.

usethebrainsgodgiveyou said...

http://www.nlm.nih.gov/medlineplus/news/fullstory_120746.html HIV exposure and language problems.

usethebrainsgodgiveyou said...

http://www.human-existence.com/publications/autism%20%20cerebral-cerebellum%20disconnection%20Med%20Hypo%2002%20Skoyles.pdf

John Skoyles --dyslexic--thalidomide day 20-24

usethebrainsgodgiveyou said...

http://www.hindawi.com/journals/aurt/2011/681627/ higher order versus non contextual processing

usethebrains godgiveyou said...

http://asdresearchinitiative.wordpress.com/2013/05/15/influenza-risk-for-bipolar-schizophrenia-and-autism/

Influenza and increase in Bipolar

usethebrains godgiveyou said...

RA Jensen http://www.oapublishinglondon.com/article/594 BAP and autism.

http://www.oapublishinglondon.com/article/578 Genetic mutations in male sperm....Luck of the draw. Also,................SSRI's?

http://www.oapublishinglondon.com/images/article/pdf/1370118463.pdf

Usethebrains Godgiveyou said...

Haiti lacks rubella immunization system...http://www.scielosp.org/scielo.php?script=sci_arttext&pid=s1020-49892002001000008

Usethebrains Godgiveyou said...

Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity.http://www.ncbi.nlm.nih.gov/pubmed/24120386 Not sure if this in included above

Usethebrains Godgiveyou said...

zika virus...rude awakening. Viral interference with brain growth. Also seems prominent in first trimester.

http://www.pbs.org/newshour/updates/zika-virus-faqs-ultrasound-detection/

http://www.ncbi.nlm.nih.gov/pubmed/24423639 CMV days~160-200 atopsy http://jnen.oxfordjournals.org/content/73/2/143.long " The density of CMV-infected cells and the tropism of CMV for progenitor cells were the major factors that determined the severity of brain abnormalities, which also included damage to the limbic system and the olfactory bulbs and the occurrence of microcephaly at early stages of brain development." Infection at later stages still capable of harm.

Usethebrains Godgiveyou said...


It occured to me, what is the transmission of virus's from mother to fetus, mostly because of the mess caused by Zika directly related to the development of the brain in the fetus.

http://emedicine.medscape.com/article/235213-overview

Viral infections in pregnancy are major causes of maternal and fetal morbidity and mortality. Infections can develop in the neonate transplacentally, perinatally (from vaginal secretions or blood), or postnatally (from breast milk or other sources). The clinical manifestations of neonatal infections vary depending on the viral agent and gestational age at exposure. The risk of infection is usually inversely related to gestational age at acquisition, some resulting in a congenital malformation syndrome.

Why are we so damned worried about the mother having a fever and it being related to schizophrenia, when it actually may be more related to the mother's transmission of the virus at a vulnerable stage? so MUCH to learn from Zika.

Usethebrains Godgiveyou said...

Great minds think alike? I wish....I did however cut and paste the previous comment to here: https://spectrumnews.org/opinion/q-and-a/questions-for-alysson-muotri-applying-autism-tools-to-zika/

A good mix to the idea of viral transmission of anomalies leading to autistic behavior, in theory.

Usethebrains Godgiveyou said...

http://questioning-answers.blogspot.com/2016/02/does-rubella-german-measles-cause-autism.html

Not sure this is here...Paul Whitely on German Measles and Autism

Usethebrains Godgiveyou said...

Teratogens and birth defects: http://www.encyclopedia.com/topic/birth_defects.aspx